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Cyclopamine(11-deoxojervine) CAS:4449-51-8 环巴胺(环杷明)Cyclopamine(11-deoxojervine)
Appearance:White crystalline solid
Assay(HPLC): >99%
Product Name: Cyclopamine(11-Deoxyjervine)
Botanical Source: Veratrum californicim (plant extract)
CAS No.: 4449-51-8
Synonyms:11-Deoxojervine; (3b,23b)-17,23-Epoxy-11-deoxoveratraman-3-ol
Chemical Name: (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,
11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol
Molecular Formula:C27H41NO2
Molecular Weight 411.62
Appearance: White to off-white powder
Solubility: Soluble in * ethanol (20mg/ml), DMSO (4mg/ml), dimethyl formamide (10mg/ml), methanol (7mg/ml). Insoluble in water.
Purity: >99% (HPLC)
Description:
Cyclopamine is a natural steroidal jerveratrum alkaloide. Cyclopamine is named after its ability to cause cyclopia(holoprosencephaly) in unborn sheep.
Cyclopamine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling. It specifically inhibits the hedgehog (Hh) pathway by interaction with the Hh signaling protein smoothened. Cyclopamine blocks the oncogenic effects of mutations of Ptch in fibroblasts and inhibits the growth of cells lacking Ptch function. It arrested cell cycle at G0/G1 and induced apoptosis in several small-cell lung cancer cell lines at 5 ?M. Cyclopamine also induces expression of the transcription factor pdx-1, which stimulates insulin secretion in differentiation protocols for mouse embryonic stem cells.
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